Repaglinide. Natiglinide. Mitiglinide.. new drugs taken by mouth in the form of tablets in patients with type II diabetes

Repaglinide. Natiglinide. Mitiglinide

Is new drugs taken by mouth in the form of tablets in patients with type II diabetes.

Advantage of these drugs quickly absorbed from the gastrointestinal tract when taken by mouth and therefore the rapid therapeutic effect. Therefore it needed to be addressed immediately before each meal. The estimated time required to obtain the highest concentration of these drugs in the blood by about 55 minutes. And these drugs is metabolized quickly by the liver and an estimated half-life of about one hour. And duration short therapeutic Mfolhm where between 3-4 hours and therefore these drugs are less likely to a sharp decline in the patient's blood sugar.

How do these drugs work?

These drugs are similar to the mechanism of action drugs sulfonylureas where to alert the secretion of the hormone insulin from the beta cells in the pancreas, but weaker than the sulfonylureas drugs.

Therapeutic dose:

Given drugs Almkulaitinad   In the form of tablets for oral dose ranging between 0.25-4 mg (maximum 16 mg   Per day). And is usually taken just before eating to reduce   The rise in blood glucose after a meal in patients with type II diabetes who can not control the level of sugar have well through sports nutrition.And can cause these drugs sharp fall in blood glucose when you delay a meal, or not taken, or they do not contain a sufficient amount of sugars.

And can   Utilization   Almkulaitinad drugs individually or with metformin. These compounds differ in chemical form for drugs sulfonylureas not contain sulfur and therefore can be used as an alternative to drugs sulfonylureas in patients with type II diabetes who are allergic to congenital sulfonylureas. These may be good medicine in patients who may be at risk for kidney problems.

Possible side effects:

• Symptoms include side drugs Almkulaitinad diarrhea and headaches.

• Ribakulainad drug may have a degree of gravity on the heart, such as sulfonylureas drugs, while new medicines, like Natakulainad may be less dangerous to the heart.

• These drugs should be used with caution in patients who suffer from poor liver function.

• May accompany the use of these drugs increased slightly in the patient's weight, but less than that resulting from the drugs sulfonylureas.